A cannabis clinical trial is a rigorous, highly controlled scientific study involving human participants designed to evaluate the safety, efficacy, and side effects of cannabis-based medicines or specific cannabinoids (like THC, CBD, or CBN). As of February 2026, the definition has shifted from “exploratory” to “pharmaceutical-grade.” With the recent federal move toward Schedule III in the U.S. and similar rescheduling globally, these trials are now the mandatory bridge for turning a state-legal “product” into a federally recognized “medication.”